It has been noted that persons with the XXY karyotype have various medical and psychological problems, such as depression, low self esteem, and lack of self confidence. It has also been noted that XXY adults are sensitive to others and have strong coping skills, and many have achieved high personal and professional status, in spite of - or because of? - their condition. Here, people who are XXY can discuss psychological issues which may relate to their XXY karyotype.

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