Off the Beat
Humorous strip written and drawn by Emily K, about kids involved with band and music.
Off the Mark
Mark Parisi's daily comic panel is on the web with a daily cartoon, archives according to subject, some stuff to buy and syndication information.
On the Fly
The chronical of Arney, a boy in a new town, in a new house with his newly divorced mom and a life that's just about to get interesting.
Order of the Stick
Fantasy role playing oriented strip - includes cast of characters and some game design articles.
Orneryboy by Michael Lalonde
A comic strip about the adventures of a really moody boy and his perky girlfriend.
OsigmaComics
Features webcomic about a school in the UK featuring all the stereotypical characters and situations like world domination.
Otaku Life
An online comic strip about the secret life of college students and anime freaks. By Jeanette Brown.
Owlie Comics
An archive featuring the grumpy owl fighting his battles with the universe.
Spoil Sports
Sports cartoons by Dominic Nunziato. A sports column in every cartoon.