Idiom Syndrome
A photo-webcomic with random humour for the most part.
In Real Life
Following the adventures of Mario, Mega Man, and Link when they are sucked out of the Super NES.
Inepto.com
Lampoons ineptitude at all levels of society, from customer service to CEOs and politicians.
Inktank.com
Two strips: Angst Technology, about a game development company, and Weak-end Warriors, about paintball.
Insane Comics
A normal sprite comic site but with a twist. Include Super Heroes In Training, Unit 003, 8 Bit Insanity, and Megaman SC.
Intershadows
Features an archive of the title, a gallery of sketches and illustrations, and the series Coolville. By Kathleen Jacques.
It's a Crock
A weekly cartoon about some of the absurdities of everyday life in America. The cartoon features Cloe and Ocks the Albino Crocks.